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What Is It
What Causes It ? Where Is It Coming From ?
Last Time, We Wrote:
A Killing Mechanism, Part I and Part II, is coming to Planet Earth, your home and our home.
It will come from Within and and it will come from Without. There will be a melding of these forces to effect a massive wipeout. The without/within portion will come from Case A and Case B of The Killing Mechanism, Part I, respectively.
Case A will come from sheer terror, confusion, and chaos, melded with that coming from other countries. This will put extreme stress on the chemistry of the organism that has been under attack for some time now (endocrine disruptors, excess polyunsaturated fats, polluted water and air, over–medication generating reactive oxygen species in excess, etc.) and is prime for a breakdown, such that its normal biological defenses will be overwhelmed. The fittest biochemistries will survive.
All organisms under attack will have to cope with enhanced Reactive Oxygen Species, excessive Shift bases formed generating Amadori shifts falling into Mallard reactions. Lipid peroxidation will be accelerated. DNA will not be able to do the Dark Repair as continual attacks on it will overcome this mechanism. Tissues will die and not have a chance at repair after a while. The onslaught will be too much for all, except the hardiest of the biochemistries. We are going to witness, throughout all this, "The Survival of The Fittest," and not realize this, until it is all over, with few remaining on Planet Earth years from now.
Case B will be that coming from within your own bodies. Keep in mind, A and B will meld, increasing the damage. Case A and Case B will become as one.
The die was cast some 50 years or more ago. Part II of The Killing Mechanism was cast some 26,000 years ago. There is no turning back. We will do as best we can to give what we know that will help one survive. In some cases, nothing can be done.
The Second portion of The Killing Mechanism, Part II, will come from without. It will come from the stars, and because of the within portion, Case B, Part I, it will reinforce itself and create massive deaths worldwide. The Second Portion of that coming from without will generate a massive kill–off, first. Then, we should, who are left alive, witness a massive die–off—around 2016 – 2020. No one can be sure of the time schedule. It may last a generation or more; or, may happen much faster because of the weakened biochemistries now presented. It was recently given that man is no longer living as long as previously, but he has lost a few years off his lifespan. He is no longer living to 70s plus but now to his later 60s.
This second portion will be due to the damage done to the genomes of humans and other species. It will take a generation or sooner, to see the what the powerful radiations in the Arm of Orion, enormous electric currents and electromagnetic fields have done to the reproducing organisms, as the Solar System moves through The Galactic Plane.
There are other denizens "waiting" for something to pass near; still others moving about such that as our Solar System comes close to them, wreaking havoc upon us and the planet.
It will take time to overcome this damage and develop adaptative chemistries such that in effect, stronger species form from the wreakage. But, in the meantime of such an Event, teratogenic formations, still births, and greatly weakened biochemistries, and altered DNA (whereby the Dark Repair or Excision Repair may not...will not...work effectively), will wreak havoc on species. A massive die–off is inevitable. But...as the die–off occurs, Mother Nature uses adaptative mechanisms to evolve a stronger organism eventually. We can not be sure of any absolute time scale, but a generation or two may pass away during this massive die–off. Some, those strongest biochemically and physically, will survive. Life has a great way of surviving.
The first part of The Killing Mechanism, Part II, will be a massive kill–off. We give nothing as absolute here and hope this is all wrong, but as you will see from what follows, there is a possibility, slim, maybe, but the possibility still exists.
We cannot tell you how best to respond in all instances: We do not know, but we do feel, there is a strong possibility that a Slate Wiper is coming, as happened 11,000 to 19,000 years ago on the sparsely populated planet earth at that time. That which is coming now will cause mass exterminations of all the various living forms. From this, the simplest of creatures, the viruses to the bacteria, to the amphibians in all the world's seas, oceans, lakes, rivers, and streams, to the fowls of the air, and on to the higher forms of animal life on planet earth will disappear never to be seen again. From this, a remodeling of species that are the hardiest will take place; some new species will develop generations from here. We can't tell for sure about the time table; nor, the species that change and those that leave the face of the Earth never to grace it again; or, new ones that develop. This we do know: This has happened a number of times in the past.
From the ashes of the Phoenix, new species will be generated and old species with stronger biochemistries that survive, will be entirely revamped in looks, intelligence, mass, and neural wiring. Life has a great way of surviving, as it did 11,000 – 19,000 years ago when the "Event" happened. And from the old template of species that survived the kill–off and grew, a massive die–off came to those creatures from that "Event," whereby the fittest of creatures survived, and the man of that survival developed a bigger brain case, had better neural wiring, and started producing art, mathematics, poetry, and music, paleontologists inform us.
This latter portion of the die–off that survives will be "survival of the fittest." This is biochemically important. We see this in molecular biology and biochemistry all the time. "It illustrates the importance of various characteristics that biological molecules play in life." — Biochemistry and Molecular Biology, 3rd. edition, Elliot & Elliot, page 159
Evolution, under the watchful eye of a prime motivator, developed two characteristics for life to take place and function as well as it does. They are: Polarity and Hydrophobicity, that are extremely important on a planet such as earth that has water, and then...life.
Another feature of life is "bonding." Those electrical attractions between and within biomolecules of lipids, proteins, carbohydrates, and DNA. Cellular dysfunction occurs when the "wiring" is forced into wrong configurations or done by outside and/or inside forces, such as Electromagnetic Pulses (EMPs) of varying strengths and frequencies, lipid peroxidations, reactive oxygen species, and so forth. Noncovalent bonds, weak bonds of electrical attraction that do not share equally, are readily broken and reformed, unless an outside or inside force is strong enough to cause a permanent breakage also involving strong covalent bonds.This feature of noncovalent bonds broken and reformed "allows noncovalent bonds to mediate the dynamic interactions that occur among molecules in the cell." —Cell and Molecular Biology: Concepts and Experiments, Gerald Karp, 1st. & 4th. Editions
"Without noncovalent bonds, such vital life activities as metabolic reactions, duplication of DNA, and movement of materials within cells could not occur." — Ibid
Noncovalent bonds are weak bonds. These bonds are easily disturbed as in the whisking of an egg white, as you'll see in The Killing Mechanism, Section Three. A force, such as that which is coming from the Stars, may disturb them, creating havoc.
Biochemistry and Molecular Biology, by Elliot & Elliot, Third Edition, page 39, writes, concerning weak bonds:
"It is their very weakness that makes them of central importance to life. The essence of almost everything in life involves biological specificity, which depends on one molecule binding to another with such exquisite precision that only the particular molecules designed by evolution to interact do so. To emphasize the point again, the precisely specific binding of molecules one to another is the basis of virtually all biological process."
An enzyme is specifice for one reaction; a hormone for a particular receptor site; proteins recognized and attached to DNA at a particular site because particular proteins controll, bind to and recognized a particular stretch of DNA. Antibodies combine with particular antigens. The case goes on and one. How are these interactions molecularly achieved and precise?
Elliot & Elliot write:
"The binding processes in the in the examples referred to depend on weak bonds and the specificity arises from:
The fact that individual bonds are so weak that several must be formed for the attachment to occur; and
The weak bonds can form only if the relevant atoms are positioned close enough to each other.
The combination of (1) and (2) means that only molecules shaped to fit their designated partner (s) can bind in this way. The two must be complementary in shape. The relationship can be so precise that, if a single atom is changed in an enzyme substrate, or in the active centre of an enzyme, the interactions do not occur (WebMaster's Emphasis)."
If something breaks these fragile bonds and keeps them apart; or, they reform in a different fashion, life or health as we have come to know it, may be vastly different, or not exist.
"Binding of substrates to an enzyme must not be so tight that the products of the reaction cannot diffuse away; gene action and reversible gene control demand that interactions are easily reversible," writes Elliot & Elliot.
"In summary, weak bonds permit precise binding between molecules and give the basis for biological specificity. Small numbers of bond spermit easy reversibility of the binding while large numbers can produce stable inter– and intramolecular interactions. The role of weak bonds in biochemistry will be more apparent when we come to the chapters on membranes, protein structure, gene structure, and gene actions" — Ibid.
Life as we know it, is about to change. For a while, it will be quite rough. Those species that are the strongest physically and/or biochemically, will survive, unless hit by the rocks coming, volcanos erupting, tidal waves three and four miles high, etc. It will get vastly better than anything we can even imagine with this new change coming—we suspect. More of all the immediate above will be explained later.
The former element, Polarity, appears to be what the universe is made up of, along with antipolarity, which projects into matter and antimatter, among other things.
Suffice it for now...the violence and senseless killings will now be on the increase. There will be more cop violence against unarmed citizens. This will escalate into more crime against police officers such that some areas will be without policemen because of the uncontrolled violence against them. They will seek other employments. There will be some cities where, if they still have police, will not venture, even with their War Wagons, into the deep ghetto inner cities. These areas will eventually burn. A firestorm will be formed that will spread to the suburbs and outlying areas. The rich will be prime targets. Madness, sheer madness will soon be evident on Planet Earth! Be prepared. We will not be speaking any longer about how to be prepared; only...be prepared.
This is coming soon as cities go bankrupt. Expect city services to be interrupted, sporadic, or even stopped. There will be laws enacted controlling movement into and out of the metropolises. Movement will be curtailed. Curfews will be set. We saw this during Hurricane Ike and others. Passes will have to be gotten for night shifts to present to the remaining law enforcement when moving about after curfews.
The Killing Mechanism
A number of basic ideas must first be burned into our memory banks. We will discuss as presented; or, later, as necessary to make ideas clearer to understand.
Some 40 to 60 years ago, we did not have all of the refined foods as we do now; nor was practically everyone on polyunsaturated fats, such as cannola oil, fish oil, etc. These highly fragile oils have peculiar things done to them, unlike saturated fats. The former all undergo lipid peroxidation, the process wherein that fat becomes rancid. Even if you just took vitamins C, E, beta–carotene, and other antioxidants and then quickly ingest fish oil and quickly follow that with more vitamin antioxidants and the mineral selenium, you cannot play catchup and stop the lipid peroxidation from occurring.
Lipid peroxidation is the process of forming rancid lipids from polyunsaturated fatty acids (PUFAs). There are some web sites that advertise that we all eat rancid fats in one stage or another regularly. They say it does not harm the body. However, you will see that eventually it does as one ages. And with all the endocrine disrupters out there and PUFAs now being ingested, mankind has about reached its limit.
In just only about 40 to 60 years, we are now reaping—and have been for some time now—what the immediate above are doing to just the American society. Birth rate down, teens mad as hell, violence eruption on teachers, cancer and heart disease still climbing (cancer next year, or this, is to replace heart disease as the number one killer).
A thing called Reactive Oxygen Species (ROS), is built into the human body. Without it, we can't live, because it is a process that is from the body necessarily using molecular oxygen (oxygen in the atmosphere). Programmed death is built into the body! Yet, we can slow it down (provided we control infections) doing certain things and being aware of this function, that can't be avoided. Oxygen is a "Sword of Damocles." It is a two–edged sword. It gives life and it takes life. It is very toxic.
Oxygen appeared on the Earth about 2.5 billion years ago. Cyanobacteria, in making food from the chemical soup at that time, spewed out its waste product, oxygen, for billions of years. This filled up the atmosphere with it. Other organisms developed and evolved and learned to use oxygen. Many species probably died, but the fittest survived. They learned how to get around its toxicity and grew and multiplied. It eventually took them out, but the species survived and continued to evolve and multiply. This same adaptation is about to occur with all species again, but in a short span of time, we feel. The templates and biochemistries are already here—they don't need to be created this time; however, we feel some definite remodelling will occur, resulting in a better species and some to many new species created.
We will discuss, in addition to Lipid Peroxidation and ROS, Spin Restrictions–thermodynamic barriers to spin inversion (this is coming!), Bond Scission, or Bond–breaking. All figure in The Killing Mechanism, whether Part I with its Cases A/B, and Part II.
We ask you to endure with us for attempting to make this simple whereby it can be understood. Wherein such simplicity is involved, unavoidably, some scientific misunderstanding can be introduced into the the subject matter. Your WebMasters also have a large number of science people studying this site to stay abreast of what is happening in our society. Some of this material is for them too. The WebMasters could write a textbook on this matter. This is not our objective in this instance. We hope it has not been over-simplified. Our job in this matter is to present the material such that one can come away from here knowing what is happening out there when it starts in full view of everyone and perhaps, have some means of surviving in relatively good health and mind, and help them avoid panicking. Being forewarned is being forearmed.
DNA Unraveling and/or Double Strand Breakage
Ionizing radiation generates oxygen free radicals and this involves other ROS. These cause oxidative stress. We see this all the time with skin cancers and skin aging as given earlier. Ionizing radiation causes superoxide anion formation. The hydroxyl radical not only attacks other biological molecules, but also the DNA of an organism, of which man and animals are.
With what is coming from the stars, it — your WebMasters feel — will be "hot & heavy," a lot of it. Radiation, that was created 34,000 years ago, landed on the earth 11,000 to 19,000 years ago. It was from a supernova explosion that occurred light years away from earth. The radiation, along with the hot spherules, decimated man. The man at that time was known as the "Paleo" man. Radiation seemed to have changed everything about him, his biomolecules, including his DNA.
We may see this again, those few that remain because their biochemistries are the "fittest" of those who survive, and radiation damage is cleared and cleaned from the organism almost as fast as it happens; but not so fast as to not generate a massive immediate kill–off, followed by a massive die–off, as given above, a generation or two or much less, later.
DNA molecules, comprising one's genetic code, are held together with noncovalent bonding. That is, the double coiled strands are two single strands intercoiled between one another, and each strand is held to the other by weak hydrogen bonding. High energy, such as that coming from the stars, will be most unrelenting. It will break the bonds, but, the strands tend to realign themselves and coil together again.
But, when the energy is unrelenting and constant and strong, the single strands have not a chance. A wipe–out will occur as the organisms can not overcome the incessant bombardment. Those who do survive, as some of the Paleo Man did, will be those who made it to caves and underground, but not before change was instituted in their being by radiation striking their cellular framework. Those who were the fittest survived and grew and developed into stronger, more intelligent beings.
Proteins, held together with interchain and intrachain bonding, will undergo similar reactions. More on this later. For now, know well that proteins have a varied job. Following is an example of this, and if these proteins are mutated by the intense radiations coming, DNA that uses these proteins will change...and not necessarily for the good.
Gerald Karp, writing in Cell and Molecular Biology: Concepts and Experiments, Fourth Edition, says:
"X-rays, gamma rays, and particles released by radioactive atoms are all described as ionizing radiation because they generate ions as they pass through matter. Millions of gamma rays pass through our bodies every minute. When these forms of radiation collide with a fragile DNA molecule, they often break both strands of the double helix. Double-strand breaks (DSBs) can also be caused by certain chemicals, including several (e.g. bleomycin) used in cancer chemotherapy, and free radicals produced by normal cellular metabolism (page 24).
"DSBs are also introduced during replication of damaged DNA. A single double-strand break can cause serious chromosome abnormalities and, ultimately, prove lethal for a cell. DSBs can be repaired by several alternate pathways. ...Cells that lack one of the proteins required for NHEJ ( the process of repair that rejoins the broken DNA strands) are very sensitive to ionizing radiation."
We have ionizing radiation coming from the Stars in the Arm of Orion as the Solar System is now moving through The Galactic Plane. What you have immediately been reading, shows the tremendous problems facing us.
Hydrogen bonding being broken, along with the "pulling apart" of ionic bonds, hydrophilic or "water loving" forces, and hydrophobic (water fearing) interactions, and van der Waals Forces, all being disrupted, will/can cause the DNA to become unraveled and with the strong forces from the Stars—and it will be—persistent and strong enough, this will "prove lethal for a cell." Double–strand breaks, not repaired under the same conditions, will cause death. One will see humans, as this is occurring, moving about; then, suddenly drop dead or dying as the life forces of life itself goes down.
There could be a cosmic–type energy shift that will have seemingly healthy people simply collapse dead in an instant from the energetic forces in the Arm of Orion we are now moving deeper into. This would be caused by what we have been discussing and what will be discussed.
Be advised: PUFAs and Rays from outer Space do not mix.
The Galactic Plane And
The Solar System's Path Through The Arm of OrionIt Takes Approximately 26,000 Years To Go From Crest (Green Wavy Line) To The Center of The Galactic Plane (White Dotted Line). It's Like A Time Line, A New Age Starts Then.
There's still more to come, but first:
What DNA Looks Like:
In the following, one can see the importance of Hydrogen Bonding. If Broken, And Not Reset, Life Dies:
An Explanation of The Two Strands and What Is Attached to Them and What Holds Them Together: Hydrogen Bonds. QuickTime Is Necessary for This Video.
ROS In regard to Lipid Peroxidation:
Reactive oxygen species generate cellular injury via the formation of lipid free radicals (L.) and lipid peroxides (LOOH), also known as lipid hydroperoxides. This is known as autoxidation by free radicals. The initiator is often the hydroxyl radical, but can be a another member of ROS. It may even be caused by microbials. The free radical auto–oxidation is not subject to spin restriction of kinetic (energy) barriers. A hydrogen atom(s) is extracted from a double bond compound, such as found in fatty acids, and auto–oxidation is initiated.
Think about all those polyunsaturated fatty acids we're told to eat...doesn't sound like much good health advice, does it? Polyunsaturated fatty acids are the major fatty acids undergoing lipid peroxidation in cell membranes of the organism.
The Ω–terminal carbons of Ω6 and Ω3 as they are degradated form the chemical, malondialdehyde (from the fatty acids with three or more double bonds. This chemical is found in the urine and blood and is used in medicine as an indicator for fatty acid damage.
Some Diseases Associated With Injury By Free Radicals
Duchenne–Type Muscular Dystrophy
Alcoholic Liver Disease
Acute Renal Failure
Alzheimer's Possibility From ROS of PUFAs
Normal metabolism: Role of oxygen in cell injury:
Oxygen is necessary for the generation of ATP from
Oxidative phosphorylation—"the production of ATP from phosphate and ADP as electrons are transferred along the electron–transport chain from NADH or FADH2 to oxygen. Most of the FADH2 is formed in the mitochondrial mattrix by the Krebs cycle (aka TCP) and fatty acid oxidation. Oxidative phosphorylation occurs in mitochondria and is the main source of ATP in aerobes (organisms that use oxygen)"—is a necessary process that uses oxygen to form ATP.
Notice the pathways here are those we have discussed earlier to generate energy and get the work done that is necessary for biochemical health. NADH and FADH2 (electron carriers) must first be formed in one place and handed off to the beginning of the electron transport system which eventually generates energy. If the mitochrondria is damaged, the Krebs cycle malfunctions or stops, if damage is wide spread. ROS damages the mitochondria. The electron transport chain can't do its job if the beginning units are not there for work distal (downstream) to it.
Eventually, the damage adds up over the years and the organism starts to falter. Fortunately, there are from a few to several hundred to about 1500 or more in a cell depending upon the energy the surrounding tissue needs. The muscle tissues have the most mitochondria with heart and kidneys following — The Facts on file Dictionary of Biochemistry, John Daintith.
"Normal oxygen metabolism continuously converts oxygen to ROS, which can cause cell injury. Various stimuli, such as radiation, inflammation, aging, and a higher than normal partial pressure of oxygen (pO2), increase the formation of ROS. Ozone and nitrious oxide are air pollutants that form free radicals in the cells of the lungs, resulting in pulmonary emphysema and pulmonary fibrosis. A lack of oxygen due to decreased blood flow from a clot (ischemia) also causes cell injury. The reintroduction of oxygen (reperfusion) enhances cellular injury due to ROS" — Basic Medical Biochemistry: A Clinical Approach, Marks, Marks, & Smith.
Free radical–mediated cellular injury:
The reactive oxygen species (ROS), superoxide and the hydroxyl radical species start lipid peroxidation in the mitochondrial membranes, cellular, and endoplasmic reticulum membrane too. The proteins in the cell can be and often are damaged from the peroxidation, the nucleus' membranes become damaged, and DNA damage occurs. With the cellular membrane damaged, water seeps in and causes cell swelling. It doesn't stop here. With oxidative damage (lipid peroxidation) to the cell membrane, there is increased permeability. And, as this occurs, there is a greatly increased influx of calcium ions.
Hold The Last Thought.
With microsecond to microsecond depolarizations of presynaptic terminals throughout the human organism, this causes the opening of voltage–gated calcium channels, through which an influx of calcium ions flows. Calcium causes nerve vesicles that are carrying neurotransmitters to fuse with the presynaptic membrane. This fusion then empties into the synaptic cleft releasing the neurotransmitters.
Actions, depending upon the neurotransmitter carried and released, cause distal (downstream) responses such that eventually, thoughts are focused, muscular coordination for bodily movement is experienced, and a multiple of other responses, physiologically (function–wise) and biochemically domino to effect a result necessary for survival and basal metabolism. Interrupt this and we can see a multiplicity of problems ranging from no energy, movement, cognitive deficits to incapacitation, and if prolonged deeply, death. For instance, the vagal nerve to the heart could stop regulating the heart rate and one could go down from bradycardia to tachycardia, or the heart just stop beating.
If massive amounts of calcium are introduced into a cell or nerve cell, problems result. Lipid peroxidation can and does cause an inhanced influx of calcium ions into cells.
Now, Hold This Thought In Conjunction With The Last:
We know that irradiation (radiation) of "living nerves in a culture with 16–Hz" causes an efflux (egress) of calcium ions from a neuron. This can and does, over time, cause problems in an organism — Cross Currents, Becker, Robert O.
Now, Let's Bring This All Together:
The tremendous influx of unsaturated (polyunsaturated) fats in the diet are causing problems, as given in the immediate above, in the cells of the body. Damage is progressing rapidly now, we feel. Peroxidation of PUFAs are increasing Calcium influx.
In the end, just the above is enough to cause one to go down, if his biochemistry is not of proper attunement to being "Survival of The Fittest" by making the microsecond to microsecond repairs and little to no "leakage" occurring. This also includes the "Dark Repair" processes for the DNA, the cellular defenses, antioxidants, and compartmentalization of lysosomes, peroxisomes, spoken of earlier, that all are in excellent working condition and the TCP (Krebs cycle) and electron transport chain, all working in unison and better ("The Fittest") than the next organism(s).
However, with what we have just been discussing, strong magnetic fields and enormous electric currents coming from the Stars, coupled with Influx and Efflux of calcium ions, such that normalcy is disturbed, we may see humans, and any animals fed these fats, go down, and this, in effect, would be part of the Wipeout coming to Planet Earth, Part of The Killing Mechanism, that's been in place for 50 or more years now.
Now, as if these thoughts are not enough, combine with them the following:
"Ca2+ ions can also be considered as cellular messengers since they diffuse into the cytoplasm and bind to various target molecules, triggering specific responses.
"...Contraction of a smooth muscle cell and exocytosis of histamine–containing secretory granules in a mast cell, both are triggered by elevated calcium levels" — Cell and Molecular Biology: Concepts and Experiments, Karp, Gerald, first publication, 1996.
Bookmark the "elevated calcium levels"in your mind for now.
Dr. Elaine N. Marieb, writing in Human Anatomy & Physiology, Sixth Edition, page 904, page 905, says:
"Histamine (his'tah–mēn), a substance that makes capillaries leaky...acts as a powerful vasodilator.
"HCL (hydrochloric acid; formed in the stomach organ for aiding in digestion of foodstuffs and sterilization of stomach contents) secretion is stimulated by three chemicals, all of which work through second–messenger systems. ACh (acetylcholine; a neurotransmitter) released by parasympathetic nerve fibers and gastrin secreted by G cells bring about their effects by increasing intracellular Ca2+ levels (WebMaster's emphasis).
"Histamine, released by mast cells in the lamina propria (stomach mucosa), acts through cyclic AMP (cAMP). When only one of the three chemicals binds to the parietal cells, HCL secretion is scanty, but when all three bind, HCL pours forth as if shot out by a high–pressure hose."
Food in the stomach causes the stomach mucosa to release histamine, which activates parietal cells to release hydrochloric acid (HCl). The increased calcium influx may cause more histamine to be released than normal, as calcium influences histamine release when food is present in the stomach organ. With excess calcium influx from polyunsaturated fat excesses in our society today, histamine must be released rather continuously in this organ, releasing hydrochloric acid even when food may not be present. However, in today's America, try finding a stomach that ain't constantly full of food!
Hmmmm....thinking about food..."Honey, where's that bit of cheese I was working on?"
Recall from reactive oxygen species, that superoxide and the powderful hydroxyl radical initiate peroxidation at a cell's membrane as well as organelle's membrane, additionally causing causing problems to various proteins contained therein. With an attack on the cell membrane itself, a massive influx of calcium ion floods into the cell to continuously bind to target molecules, causing smooth muscle contraction and excretion of histamine from mast cells. Recall also, lipid peroxidation occurs with the polyunsaturated fats—all those you are now told to eat because they are 'heart healthy.'
Basophils (another cell crucial against disease) also contain histamine–containing granules. Not only does the histamine they carry causes dilation of blood vessels but similar to the mast cells above, basophils "bind to a particular antibody (immunoglobulin E) that causes the cells to release histamine"— Ibid, page. 657.
One conclusion should be very obvious now:
Remember! Lipid Peroxidation of PUFAs increase cell permeability of Calcium ions, among other chemicals.
"When too much calcium enters a cell it activates many enzymes, prevents muscle and nerve cells from relaxing, and ultimately kills the cell" — Ray Peats Newsletter, 'Salt, energy, metabolic rate, and longevity,' January 2009.
It appears from your WebMaster's private practice, practically everyone is told to be on a low–sodium diet. Quite often, this is in conjunction with diuretics that also remove sodium and water. Unbeknowst to most, including the health care providers, one's metabolism is slowed with a lack of sodium. This low sodium diet, coupled with diuretic ingestion, not only slows metabolism, but reduces carbon dioxide production, generates inflammation, as well as causing degeneration and biochemical stress.
The converse is that sodium "stimulates energy metabolism, increases carbon dioxide production, and protects against inflammation and other maladaptive stress reactions. One important function of carbon dioxide is to regulate the movement of positively charged alkali metal ions, such as sodium and calcium" into and out of the cell. And from the immediate 'Note' above, too much calcium entering the cell stops muscle and nerve cell relaxation and this can generate excitotoxicity and kill the neuron cell and muscle cell — Ibid.
The Low Sodium diet is part of the killing mechanism that comes from within! And you won't know it for decades, if you make it through it all.
The "Purple Pill" is one of the world's most famous. A problem that will continue to increase is that of acid reflux (GERD). It may get so bad (and we are already seeing this) that brittle bones from the increased Purple Pill intake, due to increased hydrochloric acid secretion, may escalate even more dramatically than now. We may see more gastric ulcers.
The bone problem develops because the acid is greatly reduced to get the calcium out of the food ingested and proper charge placed on calcium.
Continuing with histamine...
"Histamine can cause inflammation directly as well as indirectly. Upon release of histamine by an antigen activated mast cell, permeability of vessels near the site is increased. Thus, blood fluids (including leukocytes, which participate in immune responses) enter the area causing swelling. This is accomplished due to histamine’s ability to induce phosphorylation of an intercellular adhesion protein (called (VE)-cadherin) found on vascular endothelial cells (Andriopoulou et al 1999). That is why histamine is known as being vasoactive. Gaps between the cells in vascular tissue are created by this phosphorylation, allowing blood fluids to seep out into extracellular space. Indirectly, histamine contributes to inflammation by affecting the functions of other leukocytes in the area. It has been suggested by Marone et al that histamine release triggers the release of cytokines and inflammatory mediator (sic) by some neighboring leukocytes (1999). These chemicals in turn increases the inflammatory response.
"Histamine's second type of allergic response is one of the major causes for asthma. In response to an allergen (a substance that triggers an allergic reaction), histamine, along with other chemicals, causes the contraction of smooth muscle (Schmidt et al 1999). Consequently, the muscles surrounding the airways constrict causing shortness of breath and possibly complete trachial-closure, an obviously life-threatening condition. If the effects of histamine during an allergic reaction are inhibited, the life of an allergic person can be eased (in the case of inflammation) or even saved by preventing or shortening asthma attacks. Thankfully, many effective drugs have been developed to hinder histamine's allergic response activities" —Davidson College.
Calcium is purposely kept low in a cell. Otherwise, hormones can run amok, vascular smooth muscle, stomach smooth muscle, skeletal muscle, blood platelets, cell division, secretions, endocytosis, fertilization, synaptic transmission (see neuron discussion above), metabolism, and cell movement become disorganized and dysfunctional, and death can result. Calcium is generally pumped out of a cell. If this finite control mechanism is disturbed for too long, horrendous problems can erupt in numerous cell systems and pathways.
From what has been given, it is clear that oxygen is indeedtoxic and life–giving at the same time. It should be very easy now to understand that oxygen's toxicity and oxygen's life–giving properties makes organisms that are dependent upon oxygen prime targets for the "denizens" that lie in deep space. One can readily follow that no one is immune from what is coming to Planet Earth. This, in effect, will be another test for "Survival of The Fittest."
This entails the organism's biochemistries, the ability to withstand more than normal radiations before one goes underground, the wherewithal to biochemically repair DNA and at the same time overcome Protein Carbonyls, Mallard Reactions, etc., and still survive in relative good shape. One will need a good MindSet and Outlook with health that can survive such harsh changes and move forward to survive on the planet when life gets going again—It is not the end of the world. We will discuss protein carbonyls later.
It should be very clear by now that polyunsaturated fats are very toxic.
You may have done all and lost all. This is when one says: "I've done all and now stand! I will continue to carry my cross."
Barry Halliwell (Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore) writes in
Plant Physiol. 2006 June; 141(2): 312–322, a Special Issue on Reactive Oxygen Species,
Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life:
"The field of antioxidants and free radicals is often perceived as focusing around the use of antioxidant supplements to prevent human disease. In fact, antioxidants/free radicals permeate the whole of life, creating the field of redox biology. Free radicals are not all bad, nor antioxidants all good. Life is a balance between the two: Antioxidants serve to keep down the levels of free radicals, permitting them to perform useful biological functions without too much damage (Halliwell and Gutteridge, 2006).
"This is especially true in plants, as the rest of this issue reveals. Yet some damage is inevitable, requiring repair systems to maintain cell viability. The purpose of this article is to take a broad view of the field, and highlight some of the fascinating differences between plants and other organisms."
He summarizes his work on Reactive Oxygen Species as follows:
"ROS are all over the place in plants, animals, and aerobic bacteria. We cannot live without them or we will probably die from infections. Yet, they often kill us in the end; over the long human lifespan, the continual damage by ROS, if not properly repaired (and repair efficiency tends to drop in the aged) can contribute to the age-related development of cancer, neurodegenerative diseases, and many other disorders (Ames, 1983; Halliwell and Gutteridge, 2006).
"This may be a by product of evolution; ROS are essential for defense against infection and signaling, keeping you alive until your reproduction has finished and children have grown up. Who cares if they kill you in the later postreproductive years? Evolution doesn't. So why does taking antioxidant supplements not make us live healthily for ever (WebMaster's emphasis)? Simply because the human body regulates the ROS/antioxidant balance so carefully that feeding antioxidants does not disturb it much, and oxidative damage does not decrease (Halliwell, 1999, 2000)."
Antioxidants, Contrary to Popular Belief, Can Be Harmful. And from this one finds that Obsolescence Is Built Into The Body:
Charles R. Myers (Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA) writes 'Subcellular Sites of Xenobiotic–Induced Free–Radical Generation,' reported in Free Toxicology: Target Organ Toxicology Series, edited by Kendall B. Wallace, Taylor & Francis, 1997 (pp. 25 – 44), writes:
"For each subcellular site, there are adjunctive factors that can impact free–radical generation and potential damage. One of these is the nature and concentration of cellular defense mechanisms. If present in sufficient concentration at the site of generation, they will often act to quench at least some of the radicals. In other instances, however, these defense mechanisms can themselves generate radicals and thereby serve to enhance, rather than limit, free–radical production.
"The functional and structural heterogeneity of the cells further defines the available targets at various sites for free–radical attack, and thus the potential toxicity. If highly reactive radicals are generated close to key cellular targets (e.g., lipids, DNA), the resulting damage is likely to have more profound effects for the cell. The associaton of certain species (e.g., some metals) with key cellular targets can also serve to focus high concentrations of damage to very specific sites or targets.
"Knowledge of the subcellular sites of free–radical generation is therefore one of the elements necessary to thoroughly understand free–radical toxicology. In and of itself, however, this knowledge will only provide a partial picture, as other factors will contribute to the ultimate toxic effects."
Dr. Myers illustrates natural factors in our bodies that help protect against ROS, can do the opposite and cause ROS. He writes:
"There are many cytosolic components that have the capability of generating free radicals, including common cellular reductants (e.g., NAD(P:)H, GSH (glutathione), cysteine, ascorbate 'vitamin C,') and certain enzymes (xanthine oxidase, aldehyde oxidase, glutathione reductase). The number of potential xenobiotic substrates is large, both because there are so many cell components in this group, and because some of them (e.g., GSH, ascorbate) can react with a wide variety of functional groups."
Functional groups are particular groupings of atoms that often behave as a unit and give organic molecules their physical properties, chemical activity, and solubility in aqueous solutions.
We Continue With Dr. Myers:
"In many cases, the activation process is reductive in nature, with some of the free–radical products able to undergo redox (oxidation/reduction) cycling. In other cases, the radical products are highly reactive and therefore capable of causing damage to DNA, lipids, and other cell components.
"Some of these cytosolic components can also reduce certain metals to forms that catalyze various autoxidation reactions. For some of these cytosolic enzymes, xenobiotics may enhance their ability to generate reactive oxygen species, and, in the case of xanthine oxidase, the xenobiotics can induce the conversion of the enzyme to a form capable of free–radical generation."
Let us consider a normal component in cells, spoken above by Dr. Myers, Xanthine oxidase. This is an enzyme found throughout the organism. It reduces oxygen to hydrogen peroxide in the cytosol of the cytoplasm.
It is a major factor in ischemia/reperfusion injury especially in intestinal mucosal cells. This enzyme functions relatively normal when oxygen tension in the cell is normal. But, as in reperfusion injury from ischemia, oxygen pours into the area when circulation is restored to a tissue, and this enzyme, xanthine oxidase, uses the sudden return of oxygen to generate hydrogen peroxide and the superoxide anion. These are activated oxygen species, and from the above table earlier in the document, they are known as reactive oxygen species. Hydrogen peroxide, in the presence of iron (II) or another transition metal, if not reacted upon by catalase quick enough—and there is always "leakage"—produces the hydroxyl radical, the most potent of ROS.
Injury is produced at the site of reperfusion. Reperfusion, you recall, is the reintroduction of oxygen to deprived tissues, such as in myocardial infarction. This generates the ROS that damages heart tissues, brain and other tissues when such an event occurs.
The Milk Book by William Campbell Douglas, M.D., points out that when milk is consumed "raw" from certified healthy cows by a veterinarian, the xanthine oxidase in the milk causes no harm nor damage. It goes through the body and passes out the colon
mostly. However, he writes, that when milk is homogenized, the xanthine oxidase combines with the fat of the milk and is absorbed into the organism consuming it. This generates superoxide anions and causes damage to tissues.
Many investigators feel that homogenized milk is one cause for heart disease. It has also been shown that xanthine oxidase can produce kidney damage to the tubules therein. There is a lot of kidney disease in areas that once were relatively free of it. The dysfunction began, when dairies started homogenizing milk. Many still feel certified "raw" milk is best.
Dr. Robert C. Bohinski, writing in Modern Concepts In Biochemistry, Fourth Edition, says:
"This oxidase (xanthine oxidase) is interesting because it produces the highly toxic superoxide radical (O2– .) as a byproduct. Here then is a definite need for the detoxifying role of superoxide dismutase.
"Depending on the organism, the subsequent fate of xanthine is varied. In most primates (including humans), birds, certain reptiles, and the majority of insects, xanthine is converted by the action again of xanthine to uric acid, which is excreted as the final end product of purine catabolism."
There are some products of intermediate metabolism, such as bilirubin and uric acid, that exert antioxidant effects in some tissues, but are toxic at high levels. Just consider "gout." At high levels uric acid causes extreme pain, often in the big toe joint.
When you eat meat, you eat protein. It's hard not to know now–a–days something about protein. Primarily, one knows protein is muscle. However, protein is involved in more than the big muscles of the body. It is used in a host of physiological (function) and anatomical (structure) functions. One of the main jobs of the cell's organelles, along with the genome, is to make protein for numerous functions. Protein is very important. Muscle protein, with the tendons of the body to which the large muscles of the organism are attached, conveys strength, locomotion, and shape. The large muscles of the body also help buffer against blunt trauma. They also store a certain amount of glycogen necessary for feeding into glycolysis necessary for the breakdown into energy to drive muscular machinery. Muscles themselves, when under the duress, are catabolized (broken down) to provide the glycemic amino acids to fuel the Central Nervous System for glucose.
The muscles are in a state of constant flux. When one is under intensive stress, such as that now hitting planet earth from within and from without, and growing in intensity on a regular basis, the cortisol hormone will escalate and stay elevated, representing constant stress, and people will see their bodies shrink before their eyes, if the horrendous stress is not controlled by the individual. Some stress is necessary and is balanced with anti–stress hormones. The problem is when the stress is chronic and sustained constantly. "Survival of The Fittest" will be called into play.
One, under such conditions as given, will lose muscle and fatty tissues. Dr. Brocato advises, under these inordinate trying times of the organism, to feed the stress. Have coconut oil on hand and dextrins, and maltodextrins; or, just plain sugar or glucose. The point being that the CNS (Central Nervous System) is breaking down structural proteins, fat, ... to get glucose and energy out of them. The brain will not be denied of its "fix" of regular, sequential boluses, or pulses, of glucose. It does not care if the body starves and you feel like hell. The brain gives the order to self–destruct the body and "release glucose to me to be used for energy." Such is the nature of the organism's biochemistry.
One can have on hand a compound known as "Cortisol Control" by Vitamin Research Products, carried by natural food stores. But, your best bet is to feed the stress! Feed it high quality protein from "Milk and Egg," but not soy proteins or a protein powder that has soy in it. Or, feed the stress with "Whey" protein.
Your WebMasters have found that giving "Cortisol Control" to some diabetics with high morning glucose readings, the body slowed down its burning of vital tissues of protein and fat to supply the necessary glycemic amino acids and glycerol from muscle and adipose tissue respectively to generate glucose for the Central Nervous System. The patient(s) had normal fasting morning glucose levels. We have the diabetic patients taking two "Cortisol Control" in the morning and two before bedtime.
Didn't prepare for this? Then utilize food combinations to give Mutual Supplementation of Proteins, such as corn and beans, or beans and rice. One can substitute any grain desired to be used with legumes to get complete protein. For instance, wheat, oats, rice, rye, barley, corn, etc., combined at the same feeding with legumes which are beans, peas, lentils, or even nuts. This can be in the form of "wraps" with beans (tortillas wrapped around beans, peas, lentils, or even nuts.) Many may find it extremely hard to keep their weight up during such a crisis as what is now striking Planet Earth from within and without. This crisis is going to take its toll on the very young and the very old. But many in the prime of life will go down. The reasons have been elucidated above, and will be iterated in regard to protein.
Now, with that said, protein takes various sizes and shapes for structure and function. Oxford Dictionary of Science writes:
"Any of a large group of organic compounds found in all living organisms. Proteins comprise carbon, hydrogen, oxygen, and nitrogen and most also contain sulphur, molecular weights range from 6000 to several million. Protein molecules consist of one or several long chains (polypeptides) of amino acids linked in a characteristic sequence. This sequence is called the primary structure of the protein. These polypeptides may undergo coiling or pleating, the nature and extent of which is described as the secondary structure. The three–dimensional shape of the coiled or pleated polypeptides is called the tertiary structure. Quaternary structure specifies the structural relationship of the component polypeptides."
Click Here To Get An Animated View of The Four Structured Levels of proteins. Then, Click Back To Return Here.
"Proteins may be broadly classified into globular proteins and fibrous proteins. Globular proteins have compact rounded molecules and are usually water–soluble. Of prime importance are the enzymes, proteins that catalyse biochemical reactions. Other globular proteins include the antibodies, which combine with foreign substances in the body; the carrier proteins, such as haemoglobin; the storage proteins (e.g., casein in milk and albumin in egg white), and certain hormones (e.g. insulin).
Fibrous proteins are generally insoluble in water and consist of long coiled strands or flat sheets, which confer strength and elasticity. In this category are keratin and collagen. Actin and myosin are the principal fibrous proteins of muscle, the interaction of which brings about muscle contraction. Blood clotting involves the fibrous protein called fibrin.
"When heated over 500C (1220 F) or subjected to strong acids or alkalis, proteins lose their specific tertiary structure and may form insoluble coagulates (e.g. egg white). This usually inactivates their biological properties."
There is a wealth of information in that definition. For now, just realize that the electrical connections known as bonding, primarily using hydrogen interchain and intrachain hydrogen bonding, occurs. Any thing disturbing these electrical connections cause unfurling or denaturing of the protein if the energy supplied to it is strong and intense enough. A new bonding occurs, and what was used by Mother Nature is no longer in force. One can see immediately, problems result. If a force is significant enough, as seen below, structure of the protein changes and reattachments reform differently. The force can be heat, enormous electric currents, as found in space, powerful electromagnetic fields, also found in space, or from passing hot bodies, such as a star; or, even a planet.
We are seeing this now with the everyday electromagnetic spectrum just about filled up around us from man–made fields such as cell phones. More...much more brain and eye cancer is expected in the not too distant future. One physician locally has seen three unusual type brain cancers in just one month. He asks, "Something's going on?"
Look At This Egg
Or At This Egg White:
More on Protein Bond Breaking:
Egg white, including all other proteins, consists of long chains of amino acids strung together in various configurations. It is like the beads on a chain or boxcars of railroads with the former caboose and the engine, with the caboose serving as the free amino group at one end and the free carboxyl group at the other end, representing the engine.
In an uncooked egg, the "beads" are held in a specific configuration or shape by its hydrogen bonds. These bonds keep the egg white of the raw egg from unfurling. As the egg cooks (coagulation) from whatever source of energy—on a hot pavement in the noon day sun; or, from the energy from a microwave oven; or, from the gas/electric stove top, bond breakage occurs with unravelling of the amino acids of the protein. This same cooking can occur from the nuclear blast furnance called the Sun; or, from the energies coming from the Arm of Orion as the Solar System passes through it. Regardless, we are going to see bonds break in proteins. This process is called denaturation.
As denaturation occurs, from whatever energy source, the protein unfurls (unfolds) and mixes with other amino acids of neighboring proteins and new bonds form between the protein's amino acids resulting in textural change for the egg.
The same process can occur in all forms of life containing protein. Done long enough, with enough energy, and the proteins form new compounds with neighboring amino acids, fats, carbohydrates, etc., such that we now have a Maillard reaction. This is the same process when you brown a roast in the over or on the stove top. Whatever the source of energy, if it is long and intense enough, you brown the roast. There is no way to unbrown the roast.
When that man was in the tomb for three days and "stinketh," it may be looked upon as a Maillard type reaction from dying. No way to "unbrown" the roast. But, Another came along, and, understanding the process of denaturation, carbonyl groups, with sugars mixed in with protein flesh, Schiff bases forming, and going into Amadori products forming, and the generation of a Maillard type reaction, the Man undid all that in reverse procedure, calling life back into Lazarus.
Protein is a vital component of biomolecules (lipids, proteins, carbohydrates, DNA). Proteins have a number of functions. They are macromolecules that virtually carry out all of the activity of a cell. There are at least 10,000 various proteins that have diverse functions. The proteins have a three–diminsional shape for the atoms of the molecule in the space of wherein they work, such as the human organism. This spatial relationship is known as Conformation.
This spatial relationship is held together by bonds. They are non–covalent bonds (non sharing of electrical forces), such as ionic bonds (attractive electrical forces between charged atoms, hydrogen bonds, hydrophobic interactions and van der Waals forces. Covalent bonds (shared electrical forces, electrons), such as "sulf" bridges or sulphur to sulphur bonding, also known as disulfide bridges, are stronger and not as easily broken as non–covalent bonds.
Nevertheless, the latter bonds, when present as in biomolecules, present as a strong force because their strength is additive. For instance, because there are so many hydrogen bonds between the strands of one's genetic code, the DNA double helix, a stable structure is formed. But, problems can occur, as given earlier if the force is strong enough, such as radiation from the stars, bonds can be broken.
"Being a very delicate state, the native conformation of a globular protein is subject to alteration by chemical and/or physical agents without any change in the amino acid sequence. The loss of native conformation is called denaturation. Note that with some proteins, the process is reversible; both native conformation and biological activity
can be restored.
The self–restoring ability of a completely unfolded globular polypeptide chain is particularly remarkable when one considers that it could refold in a countless number of ways. Observations of this sort provide further evidence that the secondary and tertiary levels of protein structure are predetermined by the amino acid sequence."
Recall from the above videos, proteins have primary, secondary, tertiary, and quartenary structures. These structures, especially the latter three, have conformational (spatial) organization for their actions to do what they have to do to confer function. For instance, the immunoglobulins have a globular structure, necessary for certain immune functions.
If the conformational structures come apart because the bonding is broken by acids, bases, enzymes, strong gravitational ripples, electromagnetic fields, etc., and if the bonds do not reattach at previous configurational sites, function is lost.
This, in and of itself is bad, and will possibly happen, as we go through The Galactic Plane. But it gets worse....
To better appreciate the above, let us consider the Functions of Proteins from Modern Concepts In Biochemistry, Fourth Edition:
Catalytic proteins: enzymes that accelerate and regulate reactions.
Structural proteins: lacking a true dynamic function, these are proteins that confer a molecular foundation to various parts of an organism; examples are collagen found in connective tissue of vertebrates (representing about one–third of the total protein in the body) and various proteins in the membranes of all cells.
Pay particular attention to collagen protein. It makes you look like you. It is the glue that holds you together. Don't forget it! You often hear people say, "I feel like I'm coming apart." Before too long, they truly will.
Contractile proteins: molecules that can reversibly tighten and relax their structural orientation; examples are actin and myosin in muscle tissue and other cells.
Natural–defense proteins: examples are the antibodies in the gamma globulin fraction of blood and proteins called interferons which have been linked to an anti–viral defense.
Digestive proteins: various enzymes present in gastrointestinal secretions; these catalyze the degradation of dietary foodstuffs to smaller substances; an example is trypsin.
Transport proteins: one example is hemoglobin, which transports oxygen in the blood; various others are found in cell membranes and function in the transport of substances across the membrane.
Hormonal proteins: proteins such as insulin that regulate cellular activities.
Respiratory proteins: an example is the cytochromes, which participate in the transport of electrons to suitable acceptors, such as oxygen in aerobic organisms; they may also be considered as enzymes.
Repressor proteins: proteins that regulate the expression of genes in chromosomes.
Receptor proteins: various proteins found in cell membranes; these can transmit information to the cell interior after binding with specific substances on the exterior side of the cell.
Ribosomal proteins: proteins that in association with RNA yield ribosomes, the multimolecular aggregates that participate in protein biosynthesis.
Storage proteins: used as a nutritional energy and amino acid storage pool; especially in plant seeds.
Toxin proteins: proteins in the venom of poisonous reptiles that are responsible for the toxicity to the mammalian nervous system.
Vision proteins: an example is the rhodopsins, which participate in the molecular events associated with sight.
Chromosomal proteins: proteins in association with DNA in the nucleus; the major group is the histones.
Think about the proteinaceous functions outlined above. Several things should immediately come to mind: (a) If bonding is disrupted long enough, conformational mapping for function is lost. (b) If this occurs, dysfunction results. (c) This can generate into disease, with much expense and debilitating results. (d) It all can promulgate into death. (e) Weakened life–forms can result. (f) Species wipe–out may occur, and/or; (g) new species may result in some life–forms, and (h) better species, after the kill–off, then the die–off spoken of earlier, makes manifest with stronger species formed, as happened 11,000 to 19,000 years ago when the Paleo man went down from radiation, spherules, and volcanic eruptions, etc., those that survived developed into a stronger, more intelligent species. The same happened with other organisms.
To make matters worse from the energy coming from the stars and our own star, the Sun, there are certain angles in proteins necessary for function to exist as we know and understand life. From the above, you can see that the bond energies, if broken, render the proteins unable to perform their designated functions. It is easy to understand what happens to our "Functions of Proteins" once this happens. The energy that breaks bond formation would certainly be enough to disrupt the necessary angles, Phi (f) and Psi (ψ), pronounced "fee" and "sigh."
The energy coming from the Stars in The Killing Mechanism, Part II, A combined with B, may be just enough to disrupt the bond angle formation. The proteins are arranged in helical, sheet, and random orientations in naturally occurring proteins. The L–amino acids comprise polypeptide chains and the most common configuration is the right–hand alpha helix, where
f = –480 and ψ = –570.
"Why is this specific f, ψ combination so special? Because a very stable arrangement results. And why is it stable?
"First, because there is little or no crowding of atoms, particularly among the R (organic molecules) side chain groups of the amino acids.
Second, and of greater importance because the C=O dipole and the N—H dipole of neighboring peptide bonds are optimally oriented (they are nearly coaxial) for maximum dipole–dipole interaction, thereby producing an extensive network of intrachain cooperative hydrogen bonding that holds the a helix intact" —Modern Concepts in Biochemistry, Fourth Edition.
If these bond angles are disrupted, and say, for instance a left–handed helix forms, structural hindrance (crowding) is no longer avoided beautifully as in the right–handed helix, then function, as Mother Nature intended, is lost. The R amino acid groupings of the left–handed helix do not project away from the center axis, but project more inward, creating steric hindrance. This crowding hinders the function and reaction of the R amino acid groupings. Function is disrupted because (1) crowding of atoms on the polypeptide chain occurs. And (2), extensive networking of proteins would not be there (see above Functions of Proteins). This would interrupt hydrogen bonding that holds the protein chain together and again, networking would be lost.This implies total biochemical dysfunction.
The blast from the Stars is going, we feel, to change creation...and then, nothing may happen...until a generation or so, as more extreme die–offs occur in the interim until a generation or so has passed.
This angulation of proteins is serious business in regard to the natural orientation of naturally occurring proteins in the body and elsewhere.
There's still more....
The most understood of proteins is collagen. It is a fibrous protein which is the principal component of connective tissue. Fibrous connective tissue is the major structural protein of the body. It is in most animal life. It is the most abundant protein in nearly all animals. The total body protein is approximately 30 percent collagen.
Biochemistry by Abeles, Frey, and Jencks points out:
"It is the principal insoluble protein of connective tissue, which holds together the bodies of mammals and other animals. Tendons, for example, are composed almost entirely of collagen."
Collagen's structure resembles that of a coiled rope made of three strands. It forms a left–hand helix.The strands are held by cross–links, which are a short side chain of atoms linking two chains in a polymeric material. That is, these cross–links are connecting one strand of collagen to another. The cross–links occur between lysine and hydroxylysine. These cross–links confer to the structure rigidity and inflexibility.
Because of collagen's amino acid composition and the sequence of those amino acids, coupled with cross–linking and hydrogen bonding, this protein becomes a prime candidate for a biological tough structural protein. A one–mm thread of collagen will support nearly 20 lbs of material. Hydrogen bonding stabilizes the triple helix structure of collagen.
For collagen to function normally, the amino acids proline and lysine in collagen must be hydroxylated (adding OH). There are enzymes that use molecular oxygen as the source of the —OH group. If "proline and lysine residues are not hydroxylated, hydrogen bonding within triple helices and cross–linking between triple helices cannot occur. Therefore, collagen molecules are unstable." — Basic Medical Biochemistry.
And if they are unstable, they easily come apart. "Hereditary disorders of these hydroxylation steps result in serious disturbances in which mechanical properties of tissues such as skin and ligaments are impaired." — Modern Concepts In Biochemistry, Fourth Edition.
Keep in mind that collagen is the glue that holds the body together; without it, we come apart...literally. A vitamin necessary for collagen formation in the hydroxylation process is Vitamin C. Have plenty on hand. It just may help strengthen tissues more and aid in the repair process. Collagen is found extensively in the connective tissue of skin, bone, cartilage, and the corneal stroma of the eye that gives it transparency, and in tendons.
Many people walking Planet Earth have a form of scurvy and do not know it. Their tissues are soft and leak quite readily. They bleed very easily. Their teeth are sitting in loose sockets and their gums bleed. This is a form of scurvy.
What is coming from the Stars can attack cross–linkages, and the collagen fibrils become loose and separated somewhat, with the resulting scurvy–like syndrome. The tendons formed of collagen can be loosened from their attachments and muscles, and one will literally be seen coming apart.
If we think this is foolish, we quote from Cell and Molecular Biology, by Gerald Karp, first printing, p. 251:
"The fibrils are further strengthened by covalent cross–links between lysine and hydroxylysine residues on adjacent collagen molecules.
"If these intermolecular cross–links are disrupted, as can occur in animals that have ingested b–aminopropionitrile, a toxic substance present in the seeds of the sweet pea, connective tissues may be greatly weakened."
And one will see their animals or themselves, if they have to forage for food, stagger like a drunk person and fall, unable to get up and help themselves.
We may see additionally, elongated arms, legs, etc., prior to people and animals going down. Why? Again! The connective tissues have lost their bonding and are literally becoming unglued.
Those familiar with black holes and the spaghettification effect have a basic idea that you become long and thin like spaghetti. Though, black holes are not causing this spaghettification, it is the forces from Space that may cause bond dissociation and spaghettification type of effect.
Click Below For Viewing Spaghettification:
We are seeing in our private practice something the neurologists call "spontaneous tears." This is the process whereby an artery literally shears, stretches, or tears at the endothelium, the inner layer of an artery. It repairs itself, leaving a clot that may even go to form a plaque. The clot may move distal to its place of formation, causing a stroke or death of tissues.
Neurologists explain there is no explanation as to why "spontaneous tears" occur.
In several patients we've seen and are working with currently, they, too, are given no explanation as to why this "spontaneous tear" occurs. It is not known.
In two patients, the tear happened at the carotid artery high in the brain. No surgery was performed, and the clot was dissolved by medication under emergency conditions. The patients still have numbness on the side of the scalp radiating to the ear and posteriorly. There is no cure for this, neurologists explain.
When we explained what you have been reading immediately above about vitamin C, procollagen, hydroxylation, and collagen formation, and "scurvy," one bright physician lit up, shouting, "It just might work!" He just then realized that the patient(s) just may need more vitamin C for whatever reason. We made a number of other recommendations, such as avoidance of over–exposure from the electromagnetic spectrum. Primarily, for the patients we have seen, to a one, they all had part of their cell phones, such as Blue Tooth devices, sticking out of their ear. And...to a person...that was the same side that they had the spontaneous tear! Coincidence? Perhaps, but we think not.
These people are living in terror of another spontaneous tear that just might take their life or leave them with a stroke. Our feeling is that the vitamin C will help keep the glue from coming undone.
However, there are many persons probably moving into this zone whereby their "glue" is getting more and more cocked and primed for coming undone, especially if the radial center turns out to be an enormous problem. We do not know. But, be prepared.
Hence, we have taken these patients off polyunsaturated fats (unsaturated fats/PUFA), such as corn oil, canola oil, seseme seed oil, flax seed oil, and especially the fish oils, including fish liver oil, such as cod liver oil (COD).
They are extremely toxic! The COD liver oil was shown in the late 1940s to cause cancer in dogs. Experimenters were using it as a main fat in the animal's diet...all died from cancer. The dogs that were maintained on a standard diet had only 5% death from cancer.
The fish oils have neurotoxic effects to warrant avoiding them. Additionally, there is now a culture out there advising one to ingest plenty of fish oil, especially that from fatty fish. There are enough studies now illustrating that cancer is increased by the fish oils.
The PUFAs (corn oil, seseme oil, canola oil and fish oils, etc.) all cause leaky capillaries, among other things. You don't want this when diagnosed with "Spontaneous Tear(s)". The capillaries are already leaking with this dangerous condition. Just think of this condition of one with scurvy.
The patients were placed on coconut oil. We are continually asked: "How do I use this oil?" Simply, cook with it, use it on your food, or ingest throughout a day at least two tablespoons. Coconut oil helps tame the toxicity of PUFAs.
We suggest one plant a garden now including miniature fruit trees, such as lemon and lime. People won't be stealing them as readily as pears, apples, and oranges. The former trees are not as attractive as the latter, and many do not know what to do with lemons and limes.
You need the vitamin C. Lemons and limes
will supply it in a natural form readily usable by the body. Simply pick, clean, cut in half and squeeze a few drops several times daily into tepid water and consume. Before cutting into halves, grate the outer clean peel and consume. With the pulp, containing the bioflavonoid, at the end of the day,
make a lemon "stew."
Take one a pinch or two of sugar, place in a heavy sauce pan with one and one–half cups of water; add lemon pulp and using a light boil, reduce the amalgam down to half its size. Serve warm. Consume all.
This is also very good for colds, flu, sore throats, and just the plain "blahs."
The following picture shows the importance of vitamin c from lemons/limes. Notice the pigmentation of the sailors' skin:
A Close–Up of Skin Pigmentation:
Store a little vitamin C with bioflavonoids. And while you're at it, store salt. Without it...you may not make it. Store Redmond RealSalt,Eden Sea Salt and Celtic Sea Salt. Table salt has only sodium and chloride and has been bleached white for eye appeal. You want and will need the full spectrum of minerals that Mother Nature had us evolve with. Table salt will be good for curing meats, etc.
You May Literally Witness The Flesh Coming Off Another Being, Animal...Maybe Yourself, As Seen Below:
Or, You May Witness The Following Or Be The Following:
But Still...We May Have To Contend With This Too....
Click Pole Shift To Learn More About This.
To Be Continued....
AARP Bulletin'Blue Light at Night, Blue Skies in the Morning,' Karaim, Reed. October 2006.
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Hyperspace: From The Birth of The Universe To The End of Our World with Sam Neill. BBC Video (DVD), 2001.
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Nuclear War Survival Skills: Life Saving Nuclear Facts and Self-Help Instructions, Updated and Expanded 1987 Edition by Cresson H. Kearny. Oregon Institute of Science and Medicine, 3rd printing 1990.
Organ Institute of Science and Medicine. DVDs. Disk 1- 8:
Fighting Chance: Ten feet to survival.
Emergency Medicine Presentation & Interview. Dr. Jane M. Orient.
Steel Blast Shelter Tour. Narrated by Arthur B. Robinson.
Mobile Shelter Display Tour. Narrated by Arthur B. Robinson.
Nuclear War Survival Skills Overview. Narrated by Cresson H. Kearny.
Road to the Wall
Nuclear War Survival Skills with Cresson H. Kearny.
Part 1: Expedient Blast and Radiation Shelters
Part 2: Shelter Ventilation and Various Other Survival Skills
Nuclear War Survival Skills with Cresson H. Kearny.
Part 3: Home-makeable and Commercial Fallout Radiation Meters.
Part 4: Facts About Nuclear War As Told To Teenagers.
Soviet Civil Defense:
Part 1: Introduction. Interview of Dr. Leon Goure
Part 2: Soviet Training Manuals and Books. Current Journals - Section 1.
Soviet Civil Defense
Part 3: Current Journals - Section 2. Soviet Training Film - Number 1.
Part 4: Soviet Training Films. Number 2, 3, 4, 5, and 6.
Soviet Civil Defense
Part 5: Soviet Training Films. Number 7, 8, 9, 10, and 11.
Part 6: Soviet Training Films. Number 12, 13, 14, 15, and 16.
Soviet Civil Defense
Part 7: Soviet Training Film Number 17. Soviet Civil Defense Posters. Presentation by Dr. Leon Goure. Including:
Facts About Nuclear War As Explained to School Children By Dr. Jane Orient.
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Ray Peat's Newsletter, 'Stem Cells, Cell Culture, and Culture: Issues in Regineration,' Peat, Ray. September 2007, Copyright 2007.
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The Horizon Project: Bracing For Tomorrow, Miller, Brent. 2007. We suggest everyone have this DVD. Buy several and sent to friends. Ask them to do similar. Order HereThe Long Emergency, Kunstler, James Howard. Atlantic Monthly Press, N.Y., 2005.
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Warning: The Electricity Around You May Be Hazardous To Your Health: How To Protect Yourself From EMFs and Why You Should, Sugarman, Ellen. Morris Publishing, 1992.
When Life Nearly Died: The Greatest Mass Extinction of All Time, Benton, Michael J., Thames & Hudson, 2003.
Why Zebras Don't Get Ulcers: The Acclaimed Guide to Stress, Stress – Related Diseases, and Coping, Sapolsky, Robert M., Third Edition. Owl Books, 2004.
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